| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379735 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Series of lipids 1a–d and 2a,b, with carbamate linkages between hydrocarbon chains and ammonium or tertiary amine head, which were pH sensitive, were synthesized for liposome-mediated gene delivery. The variable length of carbon chains and quaternary ammonium or neutral tertiary amine heads allowed to find the structure–function relationship of how these factors affect cationic lipids on gene delivery performance.
Graphical abstractCationic lipids 1a–d and neutral lipids 2a,b, with carbamate linkages between hydrocarbon chains and ammonium or tertiary amine head, which were pH sensitive, were synthesized for liposome-mediated gene delivery.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dongliang Liu, Jianjun Hu, Weihong Qiao, Zongshi Li, Shubiao Zhang, Lvbo Cheng,