| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379741 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
B.A. Bhat, K.L. Dhar, S.C. Puri, A.K. Saxena, M. Shanmugavel, G.N. Qazi,