| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1381773 | Bioorganic & Medicinal Chemistry Letters | 2016 | 6 Pages |
Abstract
Novel ω-phenyl substituted and unsubstituted alkyl and alkenyl imidazole derivatives were prepared and tested for their antagonist activity in vitro and in vivo at histamine H3-receptors. Some compounds showed high in vitro and in vivo H3-receptor activity despite their structure bearing no polar moiety in the centre of the molecule which is a common structural feature of all other antagonists known. Quite probably there are further in vivo effects for some compounds resulting from other receptor interactions.
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Authors
H. Stark, X. Ligneau, J.-M. Arrang, J.-C. Schwartz, W. Schunack,