| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1382282 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already, described, indicates that substitutions at position 6 or 6 and 3' in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
