Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1382953 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Solid phase synthesis of peptides containing a serine thiodiglycol phosphate residue has been achieved by following a global on-resin phosphorylation strategy with a functionalized benzyl phosphoramidite. To preclude cleavage of the acid labile thiodiglycol phosphate ester during deprotection, the thioether functionality was temporarily protected as a sulfoxide.
Synthesis of peptides containing serine thiodiglycol phosphate (1) has been achieved by following a global on-resin phosphorylation strategy with the functionalized benzyl phosphoramidite 2.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
D. Noort, D.H.J.M. Platenburg, H.P. Benschop,