| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1382954 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
New potent histamine H3-receptor antagonists containing an ether group were synthesized from 3-(1H-imidazole-4-yl)propanol and various substituted diphenylmethyl chlorides. Some of the designed ethers showed high activity at histamine H3-receptors under in vitro as well as under in vivo conditions. Their activity at histamine H1- and H2-receptors was also investigated proving a pharmacological profile.
GraphicFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
A Hüls, K Purand, H Stark, X Ligneau, J.-M Arrang, J.-C Schwartz, W Schunack,