Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
153745 | Chemical Engineering Journal | 2008 | 4 Pages |
Abstract
This paper reports the direct microchannel circular dichroism (CD) measurement method for analyzing conformational changes and orientations of macromolecules in a microchannel flow. CD is a sensitive probe for secondary structure. For that reason, we apply direct CD measurement for microchannels. Herein, we conducted the direct microchannel CD measurement method by devising an optical system in the sample chamber. Furthermore, using this CD microchannel measurement method, we studied conformational changes and orientations of long-strand DNA in an elongational flow.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Kenichi Yamashita, Masaya Miyazaki, Yoshiko Yamaguchi, Maria Portia Briones, Hiroyuki Nakamura, Hideaki Maeda,