Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1942589 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2011 | 6 Pages |
Abstract
⺠We present a critical analysis of the properties of the so-called D-pathway of proton transfer in the A-type heme-copper oxidases. ⺠The role of the D-pathway in proton translocation is analysed in terms of side chain isomerisation of the residue Glu286. ⺠The rate of proton transfer in the D-pathway depends on the product of the rate constant (k)that may be changed by mutations, and the occupancy of the protonated form of Asp132 at the channel orifice.
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Authors
MÃ¥rten Wikström, Michael I. Verkhovsky,