| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1947602 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 10 Pages |
Abstract
⺠VK3 analogues effectively inhibit Aβ aggregation. ⺠The binding affinity of VK3 analogues to Aβ is in the μM range. ⺠VK3-9 can reduce the free radical generation of Aβ. ⺠VK3-9 has a protective effect on cytotoxicity induced by Aβ. ⺠VK3 analogues have potential as anti-amyloidogenic drugs for the treatment of AD.
Keywords
MM-PBSAdichlorofluoresceinDcfDCFH-DAIC50AβROSamyloid-betaApoeapolipoprotein EThTAlzheimer's diseaseAlzheimer diseaseDegenerative diseaseThioflavin-Tdichlorofluorescein diacetateMolecular dynamicsMolecular dynamics simulationFT-IRFourier-transform infraredhalf maximal inhibitory concentrationVitamin KReactive oxygen species
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Authors
Pham Dinh Quoc Huy, Yao-Chung Yu, Son Tung Ngo, Tran Van Thao, Chin-piao Chen, Mai Suan Li, Yi-Cheng Chen,