| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1972899 | Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology | 2011 | 6 Pages |
Abstract
Flatfish begin life as up-right swimming, bilaterally symmetrical larvae that metamorphose into asymmetrically shaped juveniles that swim with a highly lateralized posture. We have previously shown that TH induces abrupt growth and mineralization of one component of the vestibular system, the otoliths, during early larval development and metamorphosis. Here we report that four of five vestibular-specific genes that we tested (alpha-tectorin, otogelin, otolith matrix protein, and otopetrins 1 and 2 that are known to be associated with otolith development in other vertebrates are up-regulated 1.5- to 7-fold in larval flatfish during spontaneous metamorphosis and/or following 72Â h of TH treatment. These findings suggest that otolith growth and development are mediated by diverse TH-responsive genes during flatfish metamorphosis.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
X. Wang, Y. Tan, Q. Sievers, B. Sievers, M. Lee, K. Burrall, A.M. Schreiber,