Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1982261 | Insect Biochemistry and Molecular Biology | 2012 | 8 Pages |
Abstract
⺠A Tuace gene duplication in T. urticae resulted in the overexpression of acetylcholinesterase (TuAChE). ⺠The resistance mutations (G228S and F439W) increased the insensitivity of TuAChE to monocrotophos. ⺠The A391T mutation did not change the kinetic properties of TuAChE but mitigated the negative impacts of F439 mutation. ⺠The resistance mutations (G228S and F439W) decreased the catalytic efficiency of TuAChE, likely causing a fitness cost. ⺠The overexpression of TuAChE compensated for the reduced catalytic activity caused by the resistance mutations.
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Authors
Deok Ho Kwon, Jae Young Choi, Yeon Ho Je, Si Hyeock Lee,