| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2009089 | Pesticide Biochemistry and Physiology | 2015 | 9 Pages |
Abstract
- TCDD suppressed apoptosis induced by various apoptotic agents in breast cancer cells.
- TCDD increased expression of anti-apoptotic markers such as RelB and COX-2 in breast cancer cells.
- TCDD-induced inhibition of apoptosis is associated with expression of IDO.
- The natural AhR ligand Kynurenine is a product of the IDO pathway and inhibits the apoptotic response like TCDD.
Keywords
EGFRTGFαIDOIL-8TCDDERKCOX-2AHRMNFPI3KNF-κBCEBPβ2,3,7,8-Tetrachlorodibenzo-p-dioxinCCAAT/enhancer-binding protein βETKIndoleamine 2, 3-dioxygenaseInterleukin 8transforming growth factor αKYNApoptosisBreast cancerCyclooxygenase-2phosphatidyl-inositol-3-kinaseextracellular signal-regulated kinasekynureninearyl hydrocarbon receptorEstrogen receptorEpidermal growth factor receptor
Related Topics
Life Sciences
Agricultural and Biological Sciences
Agronomy and Crop Science
Authors
Kanae Bekki, Helena Vogel, Wen Li, Tomohiro Ito, Colleen Sweeney, Thomas Haarmann-Stemmann, Fumio Matsumura, Christoph F.A. Vogel,