Synthesis of photoreactive ivermectin B1a derivatives and their actions on Haemonchus and Bombyx glutamate-gated chloride channels

Article ID	Journal	Published Year	Pages	File Type
2009100	Pesticide Biochemistry and Physiology	2015	9 Pages	PDF

Abstract

- Three photoreactive IVM B1a derivatives were synthesized.
- These probes displayed nanomolar affinity for GluCls.
- The probes activated homomeric nematode GluCls.

Keywords

TBDMS MLM HOBt IVM DCC Avermectin HRMS dicyclohexylcarbodiimide GABA-gated chloride channel GluCl DMAP TEVC 2,2,2-trichloroethoxycarbonyl TBDMSCl EDC Haemonchus contortus DMF t-butyldimethylsilyl 1-hydroxybenzotriazole 4-(Dimethylamino)pyridine DMSO N,N-dimethylformamide N,N-diisopropylethylamine γ-aminobutyric acid Ivermectin Troc Dimethyl sulfoxide high-resolution mass spectrometry AVM Milbemycin DIPEA Photoaffinity labeling Glutamate-gated chloride channel Bombyx mori GABA Two-electrode voltage clamp

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Life Sciences Agricultural and Biological Sciences Agronomy and Crop Science

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Synthesis of photoreactive ivermectin B1a derivatives and their actions on Haemonchus and Bombyx glutamate-gated chloride channels

Authors

Toshinori Fuse, Izumi Ikeda, Tomo Kita, Shogo Furutani, Hiromitsu Nakajima, Kazuhiko Matsuda, Fumiyo Ozoe, Yoshihisa Ozoe,