Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2009291 | Pesticide Biochemistry and Physiology | 2012 | 5 Pages |
Atrazine a potent endocrine disruptor herbicide is broadly used to control rapidly growing unwanted weeds in various cereals crops which induce adverse effects both in mammalian and avian species. In present study 96 mature male Japanese quail (Coturnix japonica) were procured and randomly kept in eight groups (A to H) each having 12 birds. Atrazine was administered orally at 0, 10, 25, 50, 100, 250 and 500 mg/kg body weight to all experimental groups. The mitomycin C at 2 mg/kg body weight was given to the birds of group B which served as a positive control. From each group 4 birds were randomly selected and harvested at day 15, 30 and 45. A significant (P < 0.05) decrease in serum total protein, serum albumin and serum testosterone values were recorded at day 45 in all treated groups. A significant increase in serum ALT and AST concentration was also recorded. Moreover, morphological alterations in nucleus of erythrocytes were also observed including blebbed nuclei, notched nuclei, lobed nuclei, vacuolated cells, binucleated cell, and cell with pear shaped and micronucleus. Overall, our results show that atrazine at higher doses induces significant serum biochemical alterations and changes in nucleus of erythrocytes.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Atrazine induced toxicity was studied in mature male Japanese quail. ► Significant decrease in serum total protein, albumin and testosterone was recorded. ► Significant increase in serum ALT and AST concentration was recorded. ► Blood films showed blebbed, notched and lobed nuclei in erythrocytes along with vacuolated, binucleated and pear shaped erythrocytes ► DNA damage was observed in the form of micronucleus in atrazine treated quail.