Coexpression with auxiliary Î² subunits modulates the action of tefluthrin on rat Nav1.6 and Nav1.3 sodium channels

Article ID	Journal	Published Year	Pages	File Type
2009831	Pesticide Biochemistry and Physiology	2011	9 Pages	PDF

Abstract

âº Tefluthrin caused only resting modification of channels expressed without Î² subunits. âº The Î²1 and Î²2 subunits did not affect resting modification of Nav1.6 channels. âº Coexpression of Nav1.3 with the Î²1 and Î²2 subunits reduced resting modification. âº Î²-Subunits were required for use-dependent modification of Nav1.6 and Nav1.3 channels.

Keywords

β Subunit Tefluthrin voltage-gated sodium channels Voltage clamp