| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2010431 | Pharmacological Reports | 2016 | 11 Pages |
Abstract
Clofibrate-induced PPAR-α stimulation changes the angiotensin II receptor profile, favors the ACE2/angiotensin-(1-7)/AT2 receptor axis decreasing the vasoconstrictor environment, activates the antioxidant defense, and facilitates endothelial nitric oxide synthase activity favoring vasodilation. This may represent a protection for the stressed heart.
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Authors
Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, Elizabeth Soria-Castro, Juan C. Torres-Narváez, Francisca Pérez-Severiano, MarÃa Sánchez-Aguilar, Margarita RamÃrez-Ortega, Luz G. Cervantes-Pérez, Gustavo S. PastelÃn-Hernández,