| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2010922 | Pharmacological Reports | 2014 | 4 Pages |
Abstract
Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured.MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals.Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.
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Authors
Cecilia Zavala-Tecuapetla, Hana Kubová, Jakub Otáhal, Grygoriy Tsenov, Pavel Mareš,