| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2011064 | Pharmacological Reports | 2011 | 4 Pages |
Abstract
Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5–8 days. We hypothesize that an accumulation of microinjuries in the brain is responsible for these “spontaneous” seizures.
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Authors
van Rijn Clementina M., Perescis Martin F.J., Lyudmila Vinogradova, Luijtelaar Gilles van,