Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2011682 | Pharmacological Reports | 2013 | 12 Pages |
Abstract
Thus, arterial SMCs upon P2X receptor activation employ an effective mechanism of the Ca2+ signal amplification, the major component of which is the Ca2+ release from the SR activated by Ca2+ influx via L-type VGCCs. This signaling pathway is engaged by depolarization of the myocyte membrane resulting from activation of P2X receptors, which, being Ca2+ permeable, per se form less effective Ca2+ signaling pathway. This study, therefore, rescales potential targets for therapeutic intervention in purinergic control of vascular tone.
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Authors
Khrystyna Yu. Sukhanova, Maksym I. Harhun, Vitali A. Bouryi, Dmitri V. Gordienko,