Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2011689 | Pharmacological Reports | 2013 | 6 Pages |
Abstract
BackgroundNo previous study has assessed whether the addition of metformin potentiates fibrate action on hemostasis in prediabetic subjects.MethodsOur study included 41 fenofibrate-treated patients with impaired glucose tolerance allocated to either metformin (3 g daily) or placebo.ResultsTwelve-week treatment with fenofibrate and metformin reduced plasma levels of fibrinogen and PAI-1 and tended to change the other hemostatic markers measured, as well as improved insulin sensitivity.ConclusionsOur results show that high-dose metformin exhibits beneficial effects on coagulation and fibrinolysis in isolated IGT patients treated with a fibrate.
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Authors
Robert Krysiak, Anna Gdula-Dymek, Bogusław Okopień,