Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2011772 | Pharmacological Reports | 2009 | 8 Pages |
Abstract
The cyclic AMP (cAMP)-binding proteins, Epac, are guanine nucleotide exchange factors for the Ras-like small GTPases. Since their discovery in 1998 and with the development of specific Epac agonists, many data in the literature have illustrated their critical role in multiple cellular events mediated by the second messenger cAMP. Given the importance of cAMP in cardiovascular physiology and physiopathology, there is a growing interest to delineate the role of these multi-domain Epac in the cardiovascular system. This review will focus on recent pharmacological and biochemical studies aiming at understanding the role of Epac in cardiomyocyte signaling and hypertrophy
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Mélanie Métrich, Eric Morel, Magali Berthouze, Laetitia Pereira, Philippe Charron, Ana-Maria Gomez, Frank Lezoualc’h,