| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2011866 | Pharmacological Reports | 2011 | 5 Pages |
Abstract
We investigated the changes in hippocampal kynurenic acid (KYNA) concentrations and the amino acids involved in neuronal activity regulation following valproate (VPA) administration (400Â mg/kg ip) in pentylenetetrazole-kindled rats (in vivo). We found a remarkably long-lasting increase in KYNA levels following VPA administration, and this effect correlated with a rise in GABA levels. No changes in the concentration of other analyzed amino acids were present. It is likely that the antiepileptic and neuroprotective properties of VPA may also be a consequence of an increase in the hippocampal KYNA concentration.
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Authors
Piotr Maciejak, Janusz Szyndler, Danuta TurzyÅska, Alicja Sobolewska, Adam PÅaźnik,