| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2012067 | Pharmacological Reports | 2011 | 9 Pages |
Abstract
Myeloperoxidase (MPO) is an important enzyme that catalyzes the reaction between hydrogen peroxide and chloride to generate hypochlorous acid, which oxidizes a range of biomolecules and has been associated with inflammatory diseases. The synthetic compounds N-phenylmaleimide (NFM) and 4-methyl-N-phenylmaleimide (Me-NFM) increased the MPO activity in vitro (of isolated enzyme and in isolated cells after animal treatment) and in vivo assays. MPO-induction may represent a good model system to investigate the molecular and cellular mechanisms of oxidative cell injury induced by activated neutrophils, and the interactions between damaging species involved in the respiratory burst.
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Authors
Vânia F. Noldin, Silvana V.G. Vigil, Rafael De Liz, Valdir Cechinel-Filho, Tânia S. Fröde, Tânia B. Creczynski-Pasa,