Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2012075 | Pharmacological Reports | 2011 | 5 Pages |
Abstract
Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. The in vitro low Mg2+ seizure model is used to emulate difficult-to-treat status epilepticus. Using this model on cultured hippocampal slices, we examined the effectiveness of desialylation in reducing persistent seizure-like activity. We show that desialylation in cultured hippocampal slices effectively suppresses seizure-like activity induced by low Mg2+. These findings suggest that targeting negatively charged sialic acids may be an effective strategy to treat status epilepticus.
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Authors
Elena Isaeva, Irina Lushnikova, Alina Savrasova, Galina Skibo, Gregory L. Holmes, Dmytro Isaev,