| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2012164 | Pharmacological Reports | 2010 | 10 Pages |
Abstract
The objective of this study was to determine the cytotoxicity, antiproliferative activity, and apoptosis induction activity of two modified glycosides – digoxin and proscillaridin A – conjugated to a generation 3 polyamidoamine dendrimer (G3 PAMAM-NH2) in hu-man breast cancer cells. The results suggest that conjugation with the G3 PAMAM-NH2 dendrimer enhances the cytotoxicity of modified digoxin and proscillaridin A both in MCF-7 and in MDA-MB-231 breast cancer cells. Additionally, the conjugate-induced apoptosis was significantly greater than apoptosis evoked by free modified digoxin and proscillaridin A.
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Authors
Katarzyna Winnicka, Krzysztof Bielawski, Anna Bielawska,