| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2043458 | Current Biology | 2009 | 4 Pages |
Abstract
SummaryCytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1β in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1β maturation and pyroptotic cell death.
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Authors
Kate Schroder, Daniel A. Muruve, Jürg Tschopp,