| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2043531 | Current Biology | 2008 | 4 Pages |
Abstract
SummaryThe two co-activators of the anaphase-promoting complex/cyclosome (APC/C), Cdc20 and Cdh1, facilitate ubiquitination by the core complex, but their role in conferring substrate specificity has been contentious. A new report reveals that Cdc20-bound APC/C initiates the timely proteolysis of many Cdh1 substrates with the exception of the Aurora kinases. Failure to degrade Aurora kinases results in abnormal anaphase microtubule organisation and premature cytokinesis.
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Authors
Fanni Gergely,