| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2045997 | Current Opinion in Plant Biology | 2011 | 8 Pages |
In multicellular organisms, each cell contains the same DNA sequence, but with different epigenetic information that determines the cell specificity. Semi-conservative DNA replication faithfully copies the parental nucleotide sequence into two DNA daughter strands during each cell cycle. At the same time, epigenetic marks such as DNA methylation and histone modifications are either precisely transmitted to the daughter cells or dynamically changed during S-phase. Recent studies indicate that in each cell cycle, many DNA replication related proteins are involved in not only genomic but also epigenomic replication. Histone modification proteins, chromatin remodeling proteins, histone variants, and RNAs participate in the epigenomic replication during S-phase. As a consequence, epigenome replication is closely linked with DNA replication during S-phase.
Research highlights► DNA replication process inherits both genomic and epigenomic information from parent strands to daughter strands. ► DNA replication faithfully copies DNA sequence information, while epigenome replication dynamically changes epigenetic modifications during cell cycles. ► Many DNA replication-related proteins are involved in both DNA and epigenome replication.
