| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2047950 | FEBS Letters | 2011 | 6 Pages |
A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière’s disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca2+ activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases.
► Inner ear EC5v cells express vasopressin, β-adrenergic, and purinergic receptors. ► Adenylate cyclase, phosphoinositidase C, and Ca2+ signaling pathways are functional. ► Vasopressin and β agonists stimulate, and ATP inhibits apical potassium secretion. ► Endolymph homeostasis is maintained by GPCR-activated hormones. ► This opens new therapeutic avenues in Menière’s disease.
