Article ID Journal Published Year Pages File Type
2047959 FEBS Letters 2011 8 Pages PDF
Abstract

Osteolytic bone diseases including osteoporosis are commonly accompanied with enhanced osteoclast formation and bone resorption. Naringin, a natural occurring flavonoid has been found to protect against retinoic acid-induced osteoporosis and improve bone quality in rats. Here, we showed that naringin perturbs osteoclast formation and bone resorption by inhibiting RANK-mediated NF-κB and ERK signaling. Naringin suppressed gene expression of key osteoclast marker genes. Naringin was found to inhibit RANKL-induced activation of NF-κB by suppressing RANKL-mediated IκB-α degradation. In addition, naringin inhibited RANKL-induced phosphorylation of ERK. This study identifies naringin as an inhibitor for osteoclast formation and bone resorption, and provides evidence that natural compounds such as naringin might be beneficial as an alternative medicine for the prevention and treatment of osteolysis.

► We investigated the osteoclastic inhibitory effect of naringin. ► Naringin perturbs osteoclast formation and bone resorption. ► Naringin suppressed gene expression of key osteoclast marker genes. ► Naringin inhibited RANKL-induced NF-κB activation and phosphorylation of ERK.

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