Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2048205 | FEBS Letters | 2010 | 5 Pages |
Abstract
The glucagon receptor antagonist BI-32169, recently isolated from Streptomyces sp., was described as a bicyclic peptide, although its primary structure comprises conserved elements of class I and class II lasso peptides. Tandem mass spectrometric and nuclear magnetic resonance spectroscopic studies revealed that BI-32169 is a lasso-structured peptide constituting the new class III of lasso peptides. The determined lasso fold opens new avenues to improve the promising biological activity of BI-32169.
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Authors
Thomas A. Knappe, Uwe Linne, Xiulan Xie, Mohamed A. Marahiel,