| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2048243 | FEBS Letters | 2011 | 6 Pages |
Abstract
Peroxisome proliferator-activated receptor (PPAR) γ ligands oppose the effect induced by angiotensin II (Ang II) to reduce oxidative stress and improve antioxidant status. In this study, Ang II inhibited catalase (CAT) and peroxisome proliferator-activated receptor γ (PPAR γ) protein and mRNA expressions. Transfection with PPAR γ small-interfering RNA (siRNA) led to a reduction in CAT expression. PPAR γ ligands enhanced CAT expression and inhibited extracellular signal-regulated kinase 1/2 activation. We further reveal that Ang II type 1 receptor is not involved in the inhibitory effects of PPAR γ ligands on Ang II stimulatory events.
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Authors
Weiwei Yang, Jia Zhang, Haiya Wang, Weili Shen, Pingjin Gao, Manpreet Singh, Ningyuan Fang,