| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2048298 | FEBS Letters | 2012 | 6 Pages |
Fibroblast growth factor receptors (FGFRs) play critical roles in craniofacial and skeletal development via multiple signaling pathways including MAPK, PI3K/AKT, and PLC-γ. FGFR-mediated signaling is modulated by several regulators. Proteins with leucine-rich repeat (LRR) and/or immunoglobulin (IG) superfamily domains have been suggested to interact with FGFRs. In addition, fibronectin leucine-rich repeat transmembrane protein 3 (FLRT3) has been shown to modulate the FGFR-mediated signaling via the fibronectin type III (FNIII) domain. Therefore proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs.
► We identified the signal sequence and its flanking region for human LRIT3. ► LRIT3 facilitates maturation of FGFR1. ► LRIT3 modulates the PLC-γ branch of the FGFR-signaling pathway. ► FNIII and TM domains of LRIT3 can influence FGFR1-signaling.
