Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2048303 | FEBS Letters | 2012 | 8 Pages |
Synapsins are neuronal phosphoproteins that coat synaptic vesicles and are believed to function in the regulation of neurotransmitter release. The signaling mechanism for short-chain free fatty acid (SCFA)-stimulated NE release was examined using primary-cultured mouse sympathetic cervical ganglion neurons. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gβγ-PLCβ3-ERK1/2-synapsin 2 signaling. Further, synapsin 2b directly interacts with activated ERK1/2 and can be phosphorylated on serine when SCFA activates sympathetic neurons.
► SCFAs increase NE release from primary-cultured sympathetic neurons via GPR41. ► Sympathetic activation by SCFA involves Gβγ, PLCβ3, ERK1/2, and synapsin 2. ► Synapsin 2 directly interacts with activated ERK1/2. ► Synapsin 2b can be phosphorylated when SCFA activates sympathetic neurons.