| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2048356 | FEBS Letters | 2011 | 6 Pages |
Abstract
RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-regulated in carcinomas. Using antisense technology, we identified that RNA post-transcriptional modification is the most significant global function of Σ RNA. Specifically, processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by hydrolysis of Σ RNA/MALAT-1. These results support the hypothesis that Σ RNA/MALAT-1 is a regulatory molecule exerting roles in RNA post-transcriptional modification.
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Authors
Rui Lin, Manami Roychowdhury-Saha, Chris Black, Andrew T. Watt, Eric G. Marcusson, Susan M. Freier, Thomas S. Edgington,