Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2048409 | FEBS Letters | 2009 | 5 Pages |
Abstract
14-3-3 Proteins are highly conserved across eukaryotes, typically encoded by multiple genes in most species. Drosophila has only two such genes, 14-3-3ζ (leo), encoding two isoforms LEOI and LEOII, and 14-3-3ε. We report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas, thus increasing 14-3-3 diversity in Drosophila. Furthermore, we used a novel approach of spatially restricted leo abrogation by RNA-interference and revealed differential LEO distribution in adult heads, with LEOIII enrichment in neurons essential for learning and memory in Drosophila.
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Authors
Georgia Messaritou, Flora Leptourgidou, Maribel Franco, Efthimios M.C. Skoulakis,