Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2048441 | FEBS Letters | 2010 | 6 Pages |
Abstract
We examined the change of protein tyrosine kinases (PTKs) expression levels in colonic epithelial cells isolated from mice in which colitis was induced by oxazolone administration, using the monoclonal antibody YK34, which cross-reacts with a wide variety of PTKs. We identified focal adhesion kinase (FAK) and found the expression level increased due to the induction of colitis. Furthermore, we found that there was a positive correlation between FAK expression and the severity of colitis. Also, FAK expression localized in the colonic epithelium but not in the lamina propria, implying FAK functions in epithelial cells during colitis formation and/or wound repairing.
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Authors
Yanju Ma, Shingo Semba, Atsuo Maemoto, Masayuki Takeuchi, Isamu Kameshita, Atsuhiko Ishida, Sanae Kato, Tsuyoshi Katoh, Yunpeng Liu, Takanobu Taniguchi,