Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2048469 | FEBS Letters | 2010 | 6 Pages |
Abstract
Deregulations of microRNA have been frequently observed in tongue squamous cell carcinoma (TSCC), but their roles in tumorigenesis are not entirely clear. Here, we reported the up-regulation of miR-24 in TSCC. MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. The direct targeting of miR-24 to the DND1 mRNA was predicted bioinformatically and confirmed by luciferase reporter gene assays. Furthermore, the miR-24-mediated change in DND1 expression suppressed the expression of cyclin-dependent kinase inhibitor 1B (CDKN1B), and also led to enhanced proliferation and reduced apoptosis in TSCC cells.
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Authors
Xiqiang Liu, Anxun Wang, Caroline E. Heidbreder, Lu Jiang, Jinsheng Yu, Antonia Kolokythas, Lei Huang, Yang Dai, Xiaofeng Zhou,