| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2048516 | FEBS Letters | 2012 | 8 Pages |
miR-20a is an important member of the miR-17–92 cluster, and its real function in cervical cancer cells is unknown. Our study demonstrated that miR-20a was upregulated in cervical cancer tissues. Overexpression of miR-20a in cervical cancer-derived cell lines, HeLa and C-33A, enhanced long-term cellular proliferation, migration and invasion, whereas inhibition of miR-20a suppressed those functions. We also confirmed that oncogenic TNKS2 is directly upregulated by miR-20a. Furthermore, suppression of TNKS2 expression could inhibit colony formation, migration and invasion of cervical cancer cells. Therefore, we concluded that miR-20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2.
► We demonstrated that miR-20a is upregulated in cervical cancer tissues. ► miR-20a promoted migration and invasion in HeLa and C-33A cells. ► Our results show that TNKS2 is directly upregulated by miR-20a. ► Knockdown of TNKS2 could inhibit colony formation, migration and invasion.
