| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2048587 | FEBS Letters | 2009 | 5 Pages |
Abstract
The cyclobutane pyrimidine dimer (CPD) is one of the major classes of cytotoxic and carcinogenic DNA photoproducts induced by UV light. Hydrogen exchange rates of the imino protons were measured for various CPD-containing DNA duplexes to better understand the mechanism for CPD recognition by XPC-hHR23B. The results here revealed that double T·G mismatches in a CPD lesion significantly destabilized six consecutive base pairs compared to other DNA duplexes. This flexibility in a DNA duplex caused at the CPD lesions with double T·G mismatches might be the key factor for damage recognition by XPC-hHR23B.
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Authors
Jongchul Bang, Young-Min Kang, Chin-Ju Park, Joon-Hwa Lee, Byong-Seok Choi,