Article ID Journal Published Year Pages File Type
2048639 FEBS Letters 2011 5 Pages PDF
Abstract

Green tea’s health benefits have been attributed to its major polyphenols, the catechins: (−)-epigallocatechin gallate (EGCG), (−)-epicatechin gallate (ECG), (−)-epigallocatechin (EGC), and epicatechin (EC). Catechins (especially EGCG) modulate a wide range of biologically important molecules, including many membrane proteins. Yet, little is known about their mechanism(s) of action. We tested the catechins’ bilayer-modifying potency using gramicidin A (gA) channels as molecular force probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency (EGCG > ECG ≫ EGC > EC). Additionally, the gallate group causes current block, as evident by brief downward current transitions (flickers).

► Green tea catechins alter lipid bilayer properties and gramicidin channel function. ► The rank order of the catechins’ effect on bilayer properties is similar to that for their biological effects. ► Gallate group containing molecules interrupt gramicidin channel current.

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Life Sciences Agricultural and Biological Sciences Plant Science
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