| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2048762 | FEBS Letters | 2010 | 8 Pages |
Abstract
Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.
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Authors
Emmanuelle Schmitt, Marie Naveau, Yves Mechulam,