Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2048861 | FEBS Letters | 2010 | 8 Pages |
Abstract
Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central event in the pathogenesis of allergic disorders. The present report shows that treatment with pentagalloylglucose (PGG) resulted in a down-regulation of FcεRI surface expression on mucosal-type murine bone marrow-derived mast cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a food-allergy mouse model and suppressed the up-regulated FcεRI surface expression on mast cells derived from the food-allergy mouse colon. These findings on PGG suggest its therapeutic potential for allergic diseases through suppressing the FcεRI surface expression.
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Authors
Natsuko Kageyama-Yahara, Yoko Suehiro, Futoshi Maeda, Shun-ichiro Kageyama, Junya Fukuoka, Tatsuo Katagiri, Takeshi Yamamoto, Makoto Kadowaki,