| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2048871 | FEBS Letters | 2010 | 8 Pages |
Abstract
We investigated the interplay between parathyroid hormone (PTH) and phosphodiesterases (PDEs) in osteoblasts. PDE4 negatively regulated PTH-induced cAMP accumulation. PDE4 inhibitor enhanced PTH-induced osteoclast formation and RANKL mRNA expression, which is partially mediated by COX-2 mRNA expression. Two CRE sites in the COX-2 promoter were required for the increase in COX-2 transcription by PDE4 inhibitor, and the expression of a dominant-negative form of CREB abolished COX-2 mRNA expression in response to PDE4 inhibitor or PTH in osteoblasts. Taken together, our data indicate that PDE4 inhibitor promotes PTH-induced osteoclast formation partially via CRE-mediated COX-2 mRNA expression.
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Authors
Hyojung Park, A Long Sae Mi No, Jung-Min Lee, Ling Chen, Soo Young Lee, Dong-Seok Lee, Mijung Yim,