Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2048930 | FEBS Letters | 2010 | 6 Pages |
Abstract
Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common α-amino acids, l-Asn-1, d-Tyr-2, d-Asn-3, l-Gln-4, l-Pro-5, d-Asn-6, l-Ser-7 and the unique β-amino acid-8 present in the iturin family. 1D and 2D NMR, as well as MS analyses, identified the β-amino acid as 3-amino-13-methyltetradec-8-enoic acid, an Iso C15 long chain β-amino acid. B. subtilis SSE4 was also found to produce iturin A. B. subtilis SSE4 culture filtrate exhibited both antifungal and antibacterial activities.
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Authors
Nopporn Thasana, Benjaphorn Prapagdee, Nuchanart Rangkadilok, Ratiboot Sallabhan, Seaim Lwin Aye, Somsak Ruchirawat, Suvit Loprasert,