| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2049017 | FEBS Letters | 2008 | 6 Pages |
Abstract
We show that transcription factor Krüppel-like factor 5 (KLF5), which is important in cardiovascular remodeling, interacts with retinoic acid receptor-alpha (RARα) to regulate downstream gene expression. Here, we investigated whether acyclic retinoid (ACR) regulates KLF5 and inhibits vascular remodeling. Co-immunoprecipitation and pull-down binding assay showed that ACR attenuates functional interaction of KLF5 and RARα. ACR affects KLF5 functions by regulating transactivation of platelet-derived growth factor A (PDGF-A) chain. ACR may be a new vascular therapy to target KLF5 in cardiovascular pathology.
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Authors
Nanae Kada, Toru Suzuki, Kenichi Aizawa, Yoshiko Munemasa, Takayoshi Matsumura, Daigo Sawaki, Ryozo Nagai,