Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049087 | FEBS Letters | 2010 | 8 Pages |
Abstract
B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign-, but not self-, antigens. In this review, we consider the pre-BCR checkpoint. Mutations or alterations that affect this checkpoint underpin the development of pre-B cell leukemias, primary immunodeficiency, and possibly, systemic autoimmunity.
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Authors
Inga-Lill MÃ¥rtensson, Nina Almqvist, Ola Grimsholm, Angelina I. Bernardi,