Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049091 | FEBS Letters | 2010 | 12 Pages |
Abstract
Substrate-binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP-binding cassette transporters for substrate uptake, ion gradient driven transporters, DNA-binding proteins, as well as channels and receptors from both pro- and eukaryotes. A wealth of structural and functional data is available on SBPs, with over 120 unique entries in the Protein Data Bank (PDB). Over a decade ago these proteins were divided into three structural classes, but based on the currently available wealth of structural data, we propose a new classification into six clusters, based on features of their three-dimensional structure.
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Authors
Ronnie P.-A. Berntsson, Sander H.J. Smits, Lutz Schmitt, Dirk-Jan Slotboom, Bert Poolman,