Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049147 | FEBS Letters | 2010 | 5 Pages |
Abstract
We developed an accurate method to predict nucleosome positioning from genome sequences by refining the previously developed method of Peckham et al. (2007) [19]. Here, we used the relative fragment frequency index we developed and a support vector machine to screen for nucleosomal and linker DNA sequences. Our twofold cross-validation revealed that the accuracy of our method based on the area under the receiver operating characteristic curve was 81%, whereas that of Peckham’s method was 75% when both of two nucleosomal sequence data obtained from independent experiments were used for validation. We suggest that our method is more effective in predicting nucleosome positioning.
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Authors
Ryu Ogawa, Noriyuki Kitagawa, Hiroki Ashida, Rintaro Saito, Masaru Tomita,