Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049159 | FEBS Letters | 2010 | 6 Pages |
Abstract
Triad 1 (2 RING [really interesting new gene] fingers and DRIL [double RING finger linked] 1) is an E3 ligase that induces apoptosis and clonogenic inhibition in myeloid cells through Gfi-1 stabilization. Here we demonstrate that Triad 1 induces apoptosis in several cancer cell lines including MCF7, A549, U2OS, and HCT 116 p53+/+ cells via its RING ligase activity. Interestingly, in these cancer cells, Triad 1-induced apoptosis is not mediated by Gfi-1 stabilization but is instead p53-dependent. Moreover, Triad 1 promotes transactivation of p53. These results suggest that Triad 1 can induce apoptosis through its ligase activity via p53 activation.
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Authors
Jin Hyuk Jung, Sun-Mi Lee, Seunghee Bae, Su-Jae Lee, In-Chul Park, Young-Woo Jin, Jae Ho Lee, Sungkwan An,